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N-acetyl-beta-glucosaminidase activity in normal and malignant leukocytes

CE Reed and JM Bennett

An improved cytochemical method demonstrating N-acetyl-beta- glucosaminidase in peripheral blood and bone marrow leukocytes is described. A significant elevation in enzyme activity in circulating monocytes from patients with solid tumor malignancies was observed. In a large series of cases of acute nonlymphocytic leukemia, elevated levels were found in the vast majority of those leukemias that had a predominant monocytic component identified either morphologically or by standard cytochemical methods. This reaction would appear to be useful as a monocyte marker.

Volume 23, Issue 10, pp. 752-757, 10/01/1975
Copyright © 1975 by The Histochemical Society


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The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 1975