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Peroxisomes in disease

S Goldfischer

Cytochemical, biochemical and morphological changes in peroxisomes have been described in human metabolic disorders, in experimental models of disease and in response to drugs and toxins. These include the cerebrohepatorenal syndromes, in which peroxisomes can not be detected and mitochondrial respiration is inhibited, atherosclerosis, alcoholic cardiomyopathy, and tolerance to oxygen toxicity. Although information on the role of peroxisomes in disease is limited, increased awareness of their widespread distribution and the availability of an improved cytochemical procedure for staining peroxisomes in human specimens should provide new insights into their function.

Volume 27, Issue 10, pp. 1371-1373, 10/01/1979
Copyright © 1979 by The Histochemical Society


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S Goldfischer, J Collins, I Rapin, B Coltoff-Schiller, C. Chang, M Nigro, V. Black, N. Javitt, H. Moser, and P. Lazarow
Peroxisomal defects in neonatal-onset and X-linked adrenoleukodystrophies
Science, January 4, 1985; 227(4682): 67 - 70.
[Abstract] [PDF]



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