Morphometry of the effect of increased experience and training on synaptic density in area CA3 of the rat hippocampusRA Altschuler
A morphometric analysis of the effect of differential experiences on synapses was performed in area CA3 of the rat hippocampus. Two methods of quantitation that used a superimposed lattice grid were employed. In the first method squares overlying synapses were measured as a proportion of the total number of squares scanned; in the second method intersections of lattice lines with synapses were counted as a proportion of the total length of lines. Both measures showed that rats which were housed in an enriched environment and received 10 weeks of training had a significant increase in total area of synaptic contacts compared to both nonenriched controls and a croup with increased motor activity.
Volume 27,
Issue 11,
pp. 1548-1550,
11/01/1979
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F. W.F. Shum, L.-J. Wu, M.-G. Zhao, H. Toyoda, H. Xu, M. Ren, R. Pinaud, S. W. Ko, Y.-S. Lee, B.-K. Kaang, et al. Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment Learn. Mem., April 10, 2007; 14(4): 304 - 312. [Abstract] [Full Text] [PDF] |
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