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Morphologic probes of polypeptide hormone receptor interactions

P Gorden, JL Carpentier, P Freychet and L Orci

Polypeptide hormones, growth factors, and a variety of other naturally occurring ligands bind specifically to receptors on the cell surface. At physiologic temperatures these ligands are internalized by cells and associate intracellularly with lysosomes. Receptor-mediated internalization provides a simple mechanism that may act to couple receptor-mediated hormone degradation with receptor-medicated receptor regulation.

Volume 28, Issue 8, pp. 811-817, 08/01/1980
Copyright © 1980 by The Histochemical Society


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The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 1980