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Evidence from thiol histochemistry for homology between the Tabby- crinkled syndrome in mice and human ectodermal dysplasia

NL Weeks and SR Blecher

Mutant mice carrying the sex-linked gene Tabby (Ta), and others carrying crinkled (cr), an autosomal mimic of Ta, were studied histochemically with respect to the sulfhydryl: disulfide ratios in their skin and hair and the SH levels in their tooth germs. As compared to normal controls, the mutant animals demonstrated significantly elevated SH:S-S ratios (skin and hair) and SH levels (tooth germs) in the ectodermal components of these tissues. This finding corresponds with previously reported biochemical data on a form of human ectodermal dysplasia (ED), and therefore supports the hypothesis that these mutations in mice may be homologous to the genes for human ED.

Volume 31, Issue 12, pp. 1407-1411, 12/01/1983
Copyright © 1983 by The Histochemical Society


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