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Rhodamine 123 alters the mitochondrial ultrastructure of cultured L1210 cells

DP Evenson, J Lee, Z Darzynkiewicz and MR Melamed

Exposure of exponentially growing L1210 cells in vitro to 5-10 micrograms/ml of rhodamine 123 (R123) for 16-48 hr inhibits cell proliferation and induces cell arrest in the G1A phase of the cell cycle. The cells remain viable during the arrest and resume growth after removal of R123; extended exposure to R123 is cytotoxic. Exposure to R123 results in morphological alterations in mitochondria of all cells observed; specifically, mitochondria of R123-treated cells are characterized by a distention of the intracristal spaces and a significant increase in the number of matrix granules. Gross morphological changes of mitochondria include formation of extended organelles and the appearance of doughnut-shaped structures.

Volume 33, Issue 4, pp. 353-359, 04/01/1985
Copyright © 1985 by The Histochemical Society


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