|
|
|
|
 |
|||
|
|||
Immunocytochemical localization of atrial natriuretic factor in the kidney, adrenal medulla, pituitary, and atrium of rat
JC McKenzie, I Tanaka, KS Misono and T Inagami
Mammalian atria have previously been shown to produce a variety of peptides with natriuretic and vasorelaxant activities. Certain of these atrial natriuretic factors (ANF) have been localized immunocytochemically in secretory granules of atrial myocytes. However, the precise sites of action and extra-atrial synthesis or accumulation of ANF have not been identified immunocytochemically. In the present study, immunoreactive ANF was detected in rat atrial myocytes, intercalated cells of the renal collecting ducts, adrenal medullary chromaffin cells, and gonadotrophs of the anterior pituitary using an antibody against synthetic rat ANF-IV (H2N-Arg-Ser-Ser-Cys-Phe-Gly- Gly- Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe- Arg- Try-COOH). The localization of ANF in specialized cells of the renal collecting tubules and ducts supports suggestions that these structures may be a site of natriuretic action of ANF. In addition, immunocytochemical localization of ANF in the rat adrenal medulla and anterior pituitary suggests the existence of alternate sites of action and/or synthesis. We believe these findings are important for a more complete understanding of the role of ANF in fluid and sodium regulation and of the participation of ANF in the development of sodium- dependent hypertension.
Volume 33,
Issue 8,
pp. 828-832,
08/01/1985
Copyright © 1985 by The Histochemical Society
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  F. J. Lai, M. C. Hsieh, S. C. Hsin, S. R. Lin, J. Y. Guh, H. C. Chen, and S. J. Shin The Cellular Localization of Increased Atrial Natriuretic Peptide mRNA and Immunoreactivity in Diabetic Rat Kidneys J. Histochem. Cytochem., November 1, 2002; 50(11): 1501 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Dornhoffer, C. Danner, and S. Li Natriuretic Peptide Receptors in the Human Endolymphatic Sac Arch Otolaryngol Head Neck Surg, April 1, 2002; 128(4): 379 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. McKenzie, Y.-W. Juan, C. R. Thomas, N. E.J. Berman, and R. M. Klein Atrial Natriuretic Peptide-like Immunoreactivity in Neurons and Astrocytes of Human Cerebellum and Inferior Olivary Complex J. Histochem. Cytochem., November 1, 2001; 49(11): 1453 - 1468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-G. Forssmann, M. Meyer, and K. Forssmann The renal urodilatin system: clinical implications Cardiovasc Res, August 15, 2001; 51(3): 450 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-J. Lai, S.-J. Shin, Y.-J. Lee, S.-R. Lin, W.-Y. Jou, and J.-H. Tsai Up-Regulation of Adrenal Cortical and Medullary Atrial Natriuretic Peptide and Gene Expression in Rats with Deoxycorticosterone Acetate-Salt Treatment Endocrinology, January 1, 2000; 141(1): 325 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ogawa, B. G. Bruneau, N. Yokota, M. L. Kuroski de Bold, and A. J. de Bold Tissue-Specific Regulation of Renal and Cardiac Atrial Natriuretic Factor Gene Expression in Deoxycorticosterone Acetate–Salt Rats Hypertension, December 1, 1997; 30(6): 1342 - 1347. [Abstract] [Full Text]
|
|
|
|
|
|
H. G Hutchinson, P. T Trindade, D. B Cunanan, C.-F. Wu, and R. E Pratt Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells Cardiovasc Res, July 1, 1997; 35(1): 158 - 167. [Abstract] [Full Text] [PDF]
|
|
| Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact |