Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jacobsson, B.
Right arrow Articles by Carlstrom, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacobsson, B.
Right arrow Articles by Carlstrom, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Transthyretin immunoreactivity in human and porcine liver, choroid plexus, and pancreatic islets

B Jacobsson, VP Collins, L Grimelius, T Pettersson, B Sandstedt and A Carlstrom

Department of Pathology, Danderyd Hospital, Sweden.

We examined transthyretin immunoreactivity (TTR-IR) in human and porcine liver, choroid plexus, and pancreatic islets with both polyclonal and monoclonal antibodies to TTR. The specificity of the immunoreactions and the effects of various fixatives were tested in immunohistochemical and dot-blot systems. B-5 fixative (mercuric chloride and sodium acetate in formalin) was the best immunopreservative. In both species, the TTR-IR in choroid plexus epithelial cells was strong and was much greater than that in hepatocytes. Glucagon cells in pancreatic islets were also strongly TTR immunoreactive. Insulin cells were slightly TTR immunoreactive in human but strongly so in porcine pancreas. The finding of TTR-IR in normal islets explains the presence of TTR-IR in human endocrine pancreatic tumors, notably glucagonomas and malignant insulinomas.

Volume 37, Issue 1, pp. 31-37, 01/01/1989
Copyright © 1989 by The Histochemical Society


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. E. Allen-Jennings, M. G. Hartman, G. J. Kociba, and T. Hai
The Roles of ATF3 in Liver Dysfunction and the Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression
J. Biol. Chem., May 24, 2002; 277(22): 20020 - 20025.
[Abstract] [Full Text] [PDF]

Home page
 INT J SURG PATHOLHome page
T. J. Giordano, L. J. Medeiros, V. Monterroso, W. M. Linehan, and M. J. Merino
Transthyretin (Prealbumin) Immunoreactivity in Renal Cell Carcinoma and Other Neoplasms
International Journal of Surgical Pathology, July 1, 1996; 4(1): 1 - 7.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
A. E. Allen-Jennings, M. G. Hartman, G. J. Kociba, and T. Hai
The Roles of ATF3 in Glucose Homeostasis. A TRANSGENIC MOUSE MODEL WITH LIVER DYSFUNCTION AND DEFECTS IN ENDOCRINE PANCREAS
J. Biol. Chem., July 27, 2001; 276(31): 29507 - 29514.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 1989