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THE EFFECT OF ASCORBIC ACID ON METACHROMASIA IN SOLUTIONS OF PROTEIN AND ACID POLYSACCHARIDE

K. N. UDUPA 1 and J. ENGLEBERT DUNPHY 1

1 Civil Surgeon, Himachal Pradesh Hospital, Snowdon, Simla, India; formerly Research Fellow in Surgery, Harvard Medical School; Assistant in Surgery, Peter Bent Brigham Hospital.

Under the conditions of these experiments the interaction between toluidine blue and heparin or chondroitin sulphate is affected quantitatively by the addition of albumin. This effect can be reversed by the addition of ascorbic acid to the solution. The mechanism of action of the ascorbic acid is a subject for further study.

Submitted on March 6, 1956


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