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Effects of vinblastine on calcium distribution pattern and Ca2+,Mg(2+)- adenosine triphosphatase in rat incisor maturation ameloblasts

DR Eisenmann, AH Salama and AM Zaki

Department of Histology, College of Dentistry, University of Illinois, Chicago.

Vinblastine is known to affect secretory and transport functions of ameloblasts. The effects of vinblastine on distribution patterns of membrane-associated calcium and Ca2+,Mg(2+)-ATPase in maturation ameloblasts were investigated cytochemically. The potassium pyroantimonate (PPA) method was used for localizing calcium and a modified Wachstein-Meisel medium was used to localize Ca2+,Mg(2+)- ATPase. Ultrastructural changes induced by vinblastine included dislocated organelles and reduction or elimination of the ruffled border of the ameloblasts. Membrane-associated calcium pyroantimonate deposits were markedly reduced. The intensity of Ca2+,Mg(2+)-ATPase reaction product was also markedly reduced by vinblastine. Concomitant reduction of membrane-associated calcium and Ca2+,Mg(2+)-ATPase lends support to a role for maturation ameloblasts in control of a cyclic pattern of influx of calcium to mineralizing enamel.

Volume 40, Issue 1, pp. 143-151, 01/01/1992
Copyright © 1992 by The Histochemical Society


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