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Enhanced synthesis of gelatinase and stromelysin by myoepithelial cells during involution of the rat mammary gland
SR Dickson and MJ Warburton
Department of Histopathology, St George's Hospital Medical School, London, United Kingdom.
During the involution of the mammary gland there is destruction of the basement membrane as the secretory alveolar structures degenerate. Immunofluorescence staining of sections of rat mammary gland with antibodies to 72 KD gelatinase (MMP-2) and stromelysin (MMP-3) revealed increased production of these two proteinases during involution. This increased expression was mostly restricted to myoepithelial cells. Increased expression during involution was also demonstrated by immunoblotting techniques. Gelatin zymography indicated that the predominant metalloproteinase present in involuting rat mammary glands was a 66 KD gelatinase.
Volume 40,
Issue 5,
pp. 697-703,
05/01/1992
Copyright © 1992 by The Histochemical Society
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