|
|
|
|
 |
|||
|
|||
Expression of tenascin in developing and adult mouse lymphoid organs
G Ocklind, J Talts, R Fassler, A Mattsson and P Ekblom
Department of Zoophysiology, Uppsala University, Sweden.
The extracellular matrix (ECM) is essential in regulating many cell functions in non-lymphoid cells, and the ECM may also play a role in the function of the immune system. Tenascin is a hexameric glycoprotein of the ECM. In mouse, two major polypeptides of MW 210 KD and 260 KD are formed by differential splicing. Northern blot screening of various mouse tissues showed that the short 6 KB tenascin message was strongly expressed in the adult thymus, whereas very little or no tenascin mRNA could be detected in spleen. In addition, immunoblotting and histological analysis with monoclonal anti-tenascin antibodies revealed the presence of tenascin in lymph nodes and spleen. In thymus, only a short-splice variant of tenascin was detected by immunoblotting, which supported the Northern blot results. Immunohistology showed that the epithelial reticular stroma in both embryonic and adult mouse thymus expressed tenascin, as did the postnatal mesenchymal reticular stroma in lymph nodes and spleen. The distribution of tenascin in the thymus was more restricted than that of fibronectin and laminin.
Volume 41,
Issue 8,
pp. 1163-1169,
08/01/1993
Copyright © 1993 by The Histochemical Society
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Saito, H. Imazeki, S. Miura, T. Yoshimura, H. Okutsu, Y. Harada, T. Ohwaki, O. Nagao, S. Kamiya, R. Hayashi, et al. A Peptide Derived from Tenascin-C Induces 1 Integrin Activation through Syndecan-4 J. Biol. Chem., November 30, 2007; 282(48): 34929 - 34937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Balogh, G. Horvath, and A. K. Szakal Immunoarchitecture of Distinct Reticular Fibroblastic Domains in the White Pulp of Mouse Spleen J. Histochem. Cytochem., October 1, 2004; 52(10): 1287 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. ten Dam, T. Hafmans, J. H. Veerkamp, and T. H. van Kuppevelt Differential Expression of Heparan Sulfate Domains in Rat Spleen J. Histochem. Cytochem., June 1, 2003; 51(6): 727 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Kaldjian, J. E. Gretz, A. O. Anderson, Y. Shi, and S. Shaw Spatial and molecular organization of lymph node T cell cortex: a labyrinthine cavity bounded by an epithelium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix Int. Immunol., October 1, 2001; 13(10): 1243 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ohta, T. Sakai, Y. Saga, S.-i. Aizawa, and M. Saito Suppression of Hematopoietic Activity in Tenascin-C-Deficient Mice Blood, June 1, 1998; 91(11): 4074 - 4083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Talts, A Weller, R Timpl, M Ekblom, and P Ekblom Regulation of mesenchymal extracellular matrix protein synthesis by transforming growth factor-beta and glucocorticoids in tumor stroma J. Cell Sci., January 6, 1995; 108(6): 2153 - 2162. [Abstract] [PDF]
|
|
|
|
|
|
S. Redick and J. Schwarzbauer Rapid intracellular assembly of tenascin hexabrachions suggests a novel cotranslational process J. Cell Sci., January 4, 1995; 108(4): 1761 - 1769. [Abstract] [PDF]
|
|
| Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact |