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Journal of Histochemistry and Cytochemistry, Vol. 45, 159-164, Copyright © 1997 by The Histochemical Society, Inc.

ARTICLE

Adrenomedullin Receptor Expression in Human Lung and in Pulmonary Tumors

Alfredo Martíneza, Mae Jean Millera, Kevin J. Cattb, and Frank Cuttittaa
a Biomarkers and Prevention Research Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland
b Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland

Correspondence to: Alfredo Martínez, Div. of Clinical Sciences, National Cancer Institute, NIH, 9610 Medical Center Dr., Rm. 300, Rockville, MD 20850-3300.

Adrenomedullin (AM) is a multifunctional regulatory peptide that stimulates cyclic AMP production in many target tissues and is highly expressed in the lung. Analysis of the distribution of the recently cloned AM receptor (AM-R) by non-radioactive in situ hybridization revealed abundant expression in the basal cells of the airway epithelium and Type II pneumocytes. The expression of AM-R in the two cell types involved in epithelial regeneration of the lung suggests that AM may be relevant in such functions as organ development, wound repair, and epithelial turnover. AM-Rs are also synthesized in vivo and in vitro by a variety of tumor cells that also express the ligand, suggesting the existence of an autocrine loop that may be involved in tumor growth stimulation. The present findings suggest that the AM/AM-R regulatory system plays a major role in respiratory physiology and lung carcinogenesis and that new functions for AM remain to be identified. (J Histochem Cytochem 45:159-164, 1997)

Key Words: human lung, lung tumors, adrenomedullin receptor, growth regulation, in situ hybridization


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