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Journal of Histochemistry and Cytochemistry, Vol. 45, 1005-1020, Copyright © 1997 by The Histochemical Society, Inc.

ARTICLE

Differential Expression of the Fibroblast Growth Factor Receptor (FGFR) Multigene Family in Normal Human Adult Tissues

Siân E. Hughesa
a Division of Histopathology, United Medical and Dental Schools, St Thomas's Campus, London, United Kingdom

Correspondence to: Siân E. Hughes, Div. of Histopathology, UMDS, St Thomas’s Campus, Lambeth Palace Road, London SE1 7EH, UK.

This report describes a systematic analysis of the expression of the fibroblast growth factor receptor (FGFR) multigene family (FGFR1, FGFR2, FGFR3, and FGFR4) in archival serial sections of normal human adult tissues representing the major organ systems, using immunohistochemical techniques. Polyclonal antisera specific for FGFR1, FGFR2, FGFR3, and FGFR4 and a three-stage immunoperoxidase technique were employed to determine the cellular distribution of these receptors at the protein level. The expression profiles for the tissue-specific cellular localization of the FGFR multigene family demonstrated widespread and striking differential patterns of expression of individual receptors in the epithelia and mesenchyme of multiple tissues (stomach, salivary glands, pancreas, thymus, ureter, and cornea) and co-expression of FGFR1-4 in the same cell types of other tissues. The widespread expression of FGFR1-4 in multiple organ systems suggests an important functional role in normal tissue homeostasis. Differences in the spatial patterns of FGFR gene expression may generate functional diversity in response to FGF-1 and FGF-2, both of which bind with equally high affinity to more than one receptor subtype. In vivo, this may lead to functional differences that are crucial for the regulation of normal physiological processes and are responsible for the pathological mechanisms that orchestrate various disease processes. (J Histochem Cytochem 45:1005-1019, 1997)

Key Words: immunolocalization, human tissues, fibroblast growth factor receptor, differential expression


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The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 1997