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Journal of Histochemistry and Cytochemistry, Vol. 46, 1189-1192, October 1998, Copyright © 1998, The Histochemical Society, Inc.

BRIEF REPORT

Cortactin Localization in Actin-containing Adult and Fetal tissues

Hong Wua and Kathleen T. Montonea
a Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

Correspondence to: Hong Wu, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104..

Cortactin is a tyrosine kinase substrate that binds to filamentous actin. It represents a highly conserved family of perimembrane signaling proteins. The human homologue of cortactin is encoded by gene EMS1, which is amplified in some human breast, head, and neck carcinomas. This study shows that cortactin is preferentially localized to the apical surfaces of the polarized epithelium, specifically, to the terminal web of small bowel epithelium and to apical surfaces of the proximal renal tubules, thyroid follicles, and bronchiolar epithelium. Cortactin is also seen in cell and tissue types with actin-based contractile capacities, including smooth and striated muscle and myoepithelium. (J Histochem Cytochem 46:1189–1191, 1998)

Key Words: cortactin, human tissue distribution, tyrosine kinase substrate, actin binding protein, apical surfaces, polarized epithelium, endothelium, muscle


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