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Journal of Histochemistry and Cytochemistry, Vol. 46, 1291-1302, November 1998, Copyright © 1998, The Histochemical Society, Inc.

ARTICLE

Expression of Heat Shock Proteins in Mouse Skin During Wound Healing

Alain F. Laplantea, Véronique Moulina, François A. Augera, Jacques Landryb, Hui Lia, Geneviève Morrowc, Robert M. Tanguayc, and Lucie Germaina
a LOEX, Hôpital du Saint-Sacrement, Québec, PQ, Canada
b Centre de Recherche en Cancérologie de l'Université Laval, L'Hôtel-Dieu de Québec, Québec, PQ, Canada
c Laboratory of Cell and Developmental Genetics, Pavillon Marchand, Université Laval, Sainte-Foy, PQ, Canada

Correspondence to: Lucie Germain, LOEX, Hôpital du Saint-Sacrement, 1050 Chemin Ste-Foy, Québec, PQ G1S 4L8, Canada..

Wound healing conditions generate a stressful environment for the cells involved in the regeneration process and are therefore postulated to influence the expression of heat shock proteins (Hsps). We have examined the expression of four Hsps (Hsp27, Hsp60, Hsp70 and Hsp90) and a keratin (keratin 6) by immunohistochemistry during cutaneous wound repair from Day 1 to Day 21 after wounding in the mouse. Hsps were constitutively expressed in normal mouse epidermis and their patterns of expression were modified during the healing process. The changes were not directly linked to the time course of the healing process but rather were dependent on the location of cells in the regenerating epidermis. In the thickened epidermis, Hsp60 was induced in basal and low suprabasal cells, Hsp70 showed a reduced expression, and Hsp90 and Hsp27 preserved a suprabasal pattern with an induction in basal and low suprabasal cells. All Hsps had a uniform pattern of expression in the migrating epithelial tongue. These observations suggest that the expression of Hsps in the neoepidermis is related to the proliferation, the migration, and the differentiation states of keratinocytes within the wound. (J Histochem Cytochem 46:1291–1301, 1998)

Key Words: wound healing, epidermis, keratinocytes, skin, mice, keratin, heat shock proteins, molecular chaperones, immunohistochemistry


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