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Journal of Histochemistry and Cytochemistry, Vol. 46, 1335-1338, November 1998, Copyright © 1998, The Histochemical Society, Inc.

BRIEF REPORT

Expression of 1,25-Dihydroxy Vitamin D3 Receptor in Breast Carcinoma

Michael Friedricha, Leyla Rafia,b, Wolfgang Tilgenb, Werner Schmidta, and Jörg Reichrathb
a Departments of Gynecology, University of the Saarland, Homburg, Germany
b Dermatology, University of the Saarland, Homburg, Germany

Correspondence to: Michael Friedrich, Universitäts-Frauenklinik, Gebäude 9, 66421 Homburg/Saar, Germany..

We investigated immunohistochemically the expression of 1,25 dihydroxy vitamin D3 receptors (VDRs) in normal human breast tissue and in breast carcinomas. For the first time, a VDR immunoreactivity score (VDR-IRS) in breast tissue is presented. Mean VDR-IRS in breast carcinomas was 7.28 compared to 1.55 in normal breast tissue. Comparing staining patterns for VDR and Ki-67, no visual correlation was found, indicating that VDR upregulation in breast carcinomas is not exclusively controlled by the proliferative activity of these tumor cells. Our study adds to the body of evidence that breast tissue may be a sensitive target organ for therapeutically applied new vitamin D analogues that exert few calcemic side effects. (J Histochem Cytochem 46:1335–1337, 1998)

Key Words: breast carcinoma, VDR score, Ki-67, immunohistochemistry


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