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Journal of Histochemistry and Cytochemistry, Vol. 46, 1423-1434, December 1998, Copyright © 1998, The Histochemical Society, Inc.

ARTICLE

Distribution of Cell Membrane-associated Proteins Along the Human Nephron

Osun Kwona, Bryan D. Myersa, Richard Sibleyb, Donald Dafoec, Edward Alfreyc, and W. James Nelsond
a Division of Nephrology, Stanford University School of Medicine, Stanford, California
b Department of Pathology, Stanford University School of Medicine, Stanford, California
c Transplant Program, Stanford University School of Medicine, Stanford, California
d Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California

Correspondence to: Bryan D. Myers, Div. of Nephrology S201, Stanford Univ. Medical Center, Stanford, CA 94305-5114..

Cytoskeletal proteins associate with specific cell adhesion complexes and membrane proteins and influence the structural and functional organization of polarized epithelial cells in the kidney. Among such proteins that have been studied in cultured cell lines and in animals are the tight junction complex (ZO-1 and occludin), the adherens cell–cell adhesion complex ({alpha}-, ß-catenin and plakoglobin), and Na+,K+-ATPase, with its associated membrane skeleton proteins ankyrin and fodrin. Although abnormal distribution of these proteins has been implicated in the pathogenesis of various renal diseases, the relevance of these findings to corresponding disease of the human kidney remains to be established. As a first step towards elucidating a role for such proteins in human kidney disease, we undertook a histochemical analysis of the distribution of these proteins in biopsy specimens of human kidney taken from healthy kidney transplant donors. We found each protein to have a characteristic subcellular localization and an intensity of staining that varied among different segments of the nephron in a manner that is consistent with discrete, segmental nephron function. (J Histochem Cytochem 46:1423–1434, 1998)

Key Words: aquaporins, immunohistochemistry, membrane skeleton, tight junction adhesion proteins, Na+,K+-ATPase, human kidney


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