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Journal of Histochemistry and Cytochemistry, Vol. 46, 313-320, Copyright © 1998, The Histochemical Society, Inc.

ARTICLE

Expression of Neuropsin mRNA in the Mouse Embryo and the Pregnant Uterus

Zu-Lin Chena, Yoshiharu Momotaa, Keiko Katoa, Manabu Taniguchia, Naoko Inouea, Sadao Shiosakaa, and Shigetaka Yoshidaa
a Department of Structural Cell Biology, Nara Institute of Science and Technology, Nara, Japan

Correspondence to: Shigetaka Yoshida, Dept. of Structural Cell Biology, NAIST, 8916-5 Takayama, Ikoma, Nara 630-01, Japan.

Neuropsin is a novel serine protease whose mRNA is expressed in the mouse central nervous system. We examined the expression of neuropsin mRNA during embryonic development using Northern and in situ hybridization in non-neural tissues. The pregnant uterus showed strong expression of neuropsin mRNA, whereas the nonpregnant uterus did not express this mRNA. Expression was first detected in the primary decidual zone at 5.5 days post coitum and was maximized at 10 days post coitum, decreasing remarkably thereafter. During mouse organogenesis, neuropsin expression was observed in the developing heart, lung, thymus, pituitary, choroid plexus, and epithelial linings of the skin, oral cavity, tongue, esophagus, and forestomach. In adult mouse organs, neuropsin mRNA was expressed in epithelial tissues covered by keratinocytes with moderate density, whereas low expression was observed in lung, thymus, and spleen. Neuropsin mRNA expression in developing organs and adult keratinocytes suggests that neuropsin is associated with extracellular matrix modifications and cell migrations. (J Histochem Cytochem 46:313–320, 1998)

Key Words: neuropsin, serine protease, decidual cell, morphogenesis, keratinocyte, mouse embryo, in situ hybridization


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