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Journal of Histochemistry and Cytochemistry, Vol. 49, 1205-1210, October 2001, Copyright © 2001, The Histochemical Society, Inc.

ARTICLE

Expression of Nerve Growth Factors in Pancreatic Neural Tissue and Pancreatic Cancer

Matthias B. Schneidera,b, Jens Standopa, Alexis Ulricha, Uwe Wittela, Helmut Friessb, Åke Andrén-Sandbergc, and Parviz M. Poura
a Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska
b Klinik für Viszeral- und Transplantationschirurgie, Inselspital, University of Bern, Bern, Switzerland
c Department of Surgery, University of Lund, Lund, Sweden

Correspondence to: Parviz M. Pour, The Eppley Institute for Research in Cancer and Allied Diseases, U. of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805. E-mail: ppour@unmc.edu

One of the characteristics of pancreatic cancer is its tendency to invade neural tissue. We hypothesized that the affinity of cancer cells for nerve tissue is related to the presence of growth factors in neural tissue and their receptors in cancer cells. Sections of pancreatic cancer and normal pancreatic tissue were examined by immunohistochemistry for the expression of the neurotrophins NGF, BDNF, NT-3, NT-4, and their receptors TrkA, TrkB, and TrkC, as well as the low-affinity receptor, p75NTR. TrkA expression was found in duct, islet, and cancer cells; TrkB was found in the {alpha}-cells of the islet only. The anti-pan-Trk antibody (TrkB3), which is presumed to recognize all three receptors, immunoreacted with duct and acinar cells in normal tissue and with cancer cells. The staining with TrkC was similar to that of TrkA. The low-affinity receptor p75NTR was expressed in the neural tissue and in scattered duct cells of the normal tissue only. Duct and acinar cells, as well as neural tissue and cancer cells, showed weak to strong immunoreactivity with NGF. NT-3 expression was noted in capillary endothelia and erythrocytes. NT-4 showed specific staining for ductule cells. The expression and distribution of neurotrophins and their receptors suggest their role in the potential of pancreatic cancer cells for neural invasion.

(J Histochem Cytochem 49:1205–1210, 2001)

Key Words: nerve growth factor, pancreas, carcinoma, invasion, nerves, immunohistochemistry


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