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Journal of Histochemistry and Cytochemistry, Vol. 49, 439-444, April 2001, Copyright © 2001, The Histochemical Society, Inc.

ARTICLE

Immunohistochemical Distribution of CD9, Heparin Binding Epidermal Growth Factor-like Growth Factor, and Integrin {alpha}3ß1 in Normal Human Tissues

Yasuhiro Nakamuraa, Kazuyo Handab, Ryo Iwamotob, Takahisa Tsukamotoa, Mitsuhiko Takahasia, and Eisuke Mekadab
a Department of Pathology, St. Mary's Hospital, Kurume University, Japan
b Division of Cell Biology, Institute of Life Science, Kurume University, Japan

Correspondence to: Yasuhiro Nakamura, Dept. of Pathology, St. Mary's Hospital, 422, Tsubukuhon-machi, Kurume-shi, Japan 830-8543. E-mail: naka@st-mary-med.or.jp

The tetra-membrane-spanning protein CD9 forms a complex with a membrane-anchored heparin binding epidermal growth factor-like growth factor (HB-EGF) and integrin {alpha}3ß1 in some human and monkey cell lines. We show here the immunohistochemical distribution of CD9, HB-EGF, and integrin {alpha}3ß1 in normal human tissues. Distribution of CD9, HB-EGF, and integrin {alpha}3ß1 was similar in various tissues, including transitional epithelium, squamous epithelium, thyroid follicular epithelium, adrenal cortex, testis, smooth muscle, and stromal fibrous tissue. However, distribution of the three proteins did not coincide in some tissues, such as lung, liver, kidney, gastric and intestinal epithelium, pancreas, salivary gland, and ovary. In striated muscle, including cardiac muscle, CD9 was present not in the muscle cells themselves but in the endomysium and perimysium, whereas HB-EGF was distributed in the muscle cells themselves. CD9 was distributed in the myelin, but HB-EGF was found in the axon of the peripheral and central nervous systems. Coincident distribution of integrin {alpha}3ß1 with others was not observed in muscles and neural tissues. In conclusion, there is a possibility of complex formation and functional cooperation of CD9 with HB-EGF and/or integrin {alpha}3ß1 in several tissues.

(J Histochem Cytochem 49:439–444, 2001)

Key Words: CD9, HB-EGF, integrin {alpha}3ß1, normal human tissues, immunohistochemistry


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