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Journal of Histochemistry and Cytochemistry, Vol. 49, 665-666, May 2001, Copyright © 2001, The Histochemical Society, Inc.

BRIEF REPORT

Differential Expression of Estradiol Receptors Alpha and Beta by Gonadotropes During the Estrous Cycle

Gwen V. Childsa,b, Geda Unabiab, and Spogmai Komakb
a Department of Anatomy, University of Arkansas for Medical Science, Little Rock, Arkansas
b Department of Anatomy and Neuroscience, University of Texas Medical Branch, Galveston, Texas

Correspondence to: Gwen V. Childs, Dept. of Anatomy, Univ. of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 510, Little Rock, AR 72205-7199.

This study focused on expression of estradiol receptors (ER) during the estrous cycle. Labeling for ER{alpha} or ß antigens and luteinizing hormone (LH) or follicle-stimulating hormone (FSH) ß-subunits was done on freshly dispersed pituitary cells. The lowest expression of ER{alpha} and ß was seen in estrus (23% and 12%, respectively). Expression increased to 42–54% of pituitary cells by diestrus. In males, cells with ER{alpha} or ß were 37% or 20% of the population, respectively. ER{alpha} or ß and gonadotropin antigens were in 6–9% of pituitary cells from male rats. Early in the cycle (estrus and metestrus), less than 5% of pituitary cells expressed ER{alpha} or ß with gonadotropins. These values doubled to reach a peak of 10% during proestrus (just before ovulation). These data show that a rise in expression of both ER{alpha} and ERß is a part of preovulatory differentiation of pituitary gonadotropes.

(J Histochem Cytochem 49:665–666, 2001)

Key Words: estrous cycle, estrogen receptors, pituitary cells, differentiation


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