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Journal of Histochemistry and Cytochemistry, Vol. 49, 793-794, June 2001, Copyright © 2001, The Histochemical Society, Inc.

BRIEF REPORT

The Presence of v-abl-transformed V3 Mast Cells in the Lungs Augments Pulmonary Vascular Permeability to Acid Aspiration

Chandrika Mukundana, Michael F. Gurishc, K. Frank Austenc, Herbert B. Hechtmana, and Daniel S. Friendb
a Departments of Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
b Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
c Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts

Correspondence to: Daniel S. Friend, Div. of Rheumatology and Immunology, Smith Building, Rm. 628, One Jimmy Fund Way, Boston, MA 02115.

Acid aspiration causes pulmonary vascular permeability and PMN sequestration. By increasing pulmonary mast cells through adoptive transfer of v-abl-transformed mast cells (V3MCs) into BALB/c mice, we now show that the greater mast cell number in the lung is associated with increased pulmonary injury. (J Histochem Cytochem 49:793–794, 2001)

Key Words: alveolitis, mast cells, polymorphonuclear cells, vascular permeability


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