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Journal of Histochemistry and Cytochemistry, Vol. 49, 925-926, July 2001, Copyright © 2001, The Histochemical Society, Inc.

BRIEF REPORT

Monitoring Signal Transduction in Cancer: From Chips to FISH

Robert A. Lerscha, Jingly Fungb, H.-Ben Hsieha, Jan Smidac, and Heinz-Ulrich G. Weiera
a Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California
b School of Medicine, University of California, San Francisco, California
c Arbeitsgruppe Zytogenetik, gsf-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany

Correspondence to: Robert A. Lersch, Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 74-157, Berkeley, CA 94720. E-mail: ralersch@lbl.gov

The microarray format of RNA transcript analysis should provide new clues to carcinogenic processes. Because of the complex and heterogeneous nature of most tumor samples, histochemical techniques, particularly RNA fluorescent in situ hybridization (FISH), are required to test the predictions from microarray expression experiments. Here we describe our approach to verify new microarray data by examining RNA expression levels of five to seven different transcripts in a very few cells via FISH. (J Histochem Cytochem 49:925–926, 2001)

Key Words: spectral imaging, FISH, microarray, RNA, cancer


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