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Journal of Histochemistry and Cytochemistry, Vol. 49, 1065-1066, August 2001, Copyright © 2001, The Histochemical Society, Inc.

BRIEF REPORT

Distribution of MAP2 in Hippocampus and Cerebellum of Young and Old Rats by Quantitative Immunohistochemistry

Giuseppina Di Stefanoa, Tiziana Casolia, Patrizia Fattorettia, Natascia Gracciottia, Moreno Solazzia, and Carlo Bertoni–Freddaria
a Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121, Ancona, Italy

Correspondence to: Giuseppina Di Stefano, Neurobiology of Aging Lab., INRCA Research Department, Via Birarelli 8, Ancona AN 60121, Italy. E-mail: g.distefano@inrca.it

The microtubule-associated protein MAP2 is a cytoskeletal protein that plays a regulatory role in neuronal plasticity and in maintaining the morphology of differentiated neurons. MAP2 distribution was assessed in hippocampus and cerebellum of young and old rats by quantitative immunohistochemistry. In old vs young rats, densitometric analysis showed a significant decrease of MAP2 immunoreactivity in the hippocampus CA1 field (-93%), whereas no difference was found in cerebellar MAP2 distribution. These preliminary data suggest that in areas of the brain involved in memory acquisition and consolidation, MAP2-dependent neuroplasticity and structural integrity are significantly decreased in aging. (J Histochem Cytochem 49:1065–1066, 2001)

Key Words: microtubules, MAP2, hippocampus, cerebellum


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