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Journal of Histochemistry and Cytochemistry, Vol. 50, 107-112, January 2002, Copyright © 2002, The Histochemical Society, Inc.

BRIEF REPORT

Expression of the Gene Encoding the LIM Protein CRP2: A Developmental Profile

James R. Hendersona, Doris Brownb, James A. Richardsonc, Eric N. Olsonb, and Mary C. Beckerlea
a Department of Biology/Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah
b Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas
c Department of Pathology, Molecular Cardiology Research Laboratories, University of Texas Southwestern Medical Center, Dallas, Texas

Correspondence to: Mary C. Beckerle, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112-0840. E-mail: mary.beckerle@hci.utah.edu

Members of the cysteine-rich protein (CRP) family are evolutionarily conserved Lin-11, Isl-1, Mac-3 (LIM) domain proteins that have been implicated in cell differentiation. Here we describe the expression pattern of the CRP family member CRP2 in mouse. Unlike other CRP family members, which are expressed primarily in muscle, CRP2 is more broadly expressed. In addition to expression in vascular smooth muscle cells, we also detect CRP2-specific transcripts in mesenchymal derivatives and several epithelia.

(J Histochem Cytochem 50:107–111, 2002)

Key Words: development, LIM domains, kidney, epithelia, mesenchyme, vascular smooth muscle, lamina propria, heart, heart valves


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