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Journal of Histochemistry and Cytochemistry, Vol. 50, 1543-1554, November 2002, Copyright © 2002, The Histochemical Society, Inc.

ARTICLE

Expression of Myosin Heavy Chain Isoforms Along Intrafusal Fibers of Rat Soleus Muscle Spindles After 14 Days of Hindlimb Unloading

L. De-Donckera, F. Picqueta, G. Butler Browneb, and M. Falempina
a Laboratoire de Plasticité Neuromusculaire, Université des Sciences et Technologies de Lille 1, Villeneuve d'Ascq, France
b UMR CNRS 7000, Faculté de Médecine Paris 6, Paris, France

Correspondence to: L. De-Doncker, Laboratoire de Plasticité Neuromusculaire, EA 1032, IFR 118, Bât. SN4, Université des Sciences et Technologies de Lille 1, 59655 Villeneuve d'Ascq Cedex, France. E-mail: neuromus@pop.univ-lille1.fr

Morphological, contractile, histochemical, and electrophoretical characteristics of slow postural muscles are altered after hindlimb unloading (HU). However, very few data on intrafusal fibers (IFs) are available. Our aim was to determine the effects of 14 days of hindlimb unloading on the morphological and immunohistochemical characteristics of IF in rat soleus muscle. Thirty-three control and 32 unloaded spindles were analyzed. The number and distribution of muscle spindles did not appear to be affected after unloading. There was no significant difference in number, cross-sectional area, and histochemical properties of IF between the two groups. However, after unloading, a significant decrease in slow type 1 MHC isoform and a slight increase in slow-tonic MHC expression were observed in the B and C regions of the bag1 fibers. The {alpha}-cardiac MHC expression was significantly decreased along the entire length of the bag2 fibers and in the B and C regions of the bag1 fibers. In 12 muscle spindles, the chain fibers expressed the slow type 1 and {alpha}-cardiac MHC isoforms over a short distance of the A region, although these isoforms are not normally expressed. The most striking finding of the study was the relative resistance of muscle spindles to perturbation induced by HU. (J Histochem Cytochem 50:1543–1553, 2002)

Key Words: rat, soleus, hindlimb unloading, intrafusal fibers, histochemistry, myosin heavy chain isoforms


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