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Journal of Histochemistry and Cytochemistry, Vol. 50, 305-309, March 2002, Copyright © 2002, The Histochemical Society, Inc.

RAPID COMMUNICATION

Immunocytochemical Demonstration of the Equilibrative Nucleoside Transporter rENT1 in Rat Sinoatrial Node

H. Musaa, H. Dobrzynskia, Z. Berryb, F. Abidib, C.E. Cassd, J.D. Youngc, S.A. Baldwinb, and M.R. Boyetta
a School of Biomedical Sciences, University of Alberta, Edmonton, Alberta, Canada
b School of Biochemistry and Molecular Biology, University of Alberta, Edmonton, Alberta, Canada
c University of Leeds, Leeds, United Kingdom, and Membrane Transport Research Group, Departments of Physiology, University of Alberta, Edmonton, Alberta, Canada
d Oncology, University of Alberta, Edmonton, Alberta, Canada

Correspondence to: M.R. Boyett, School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK. E-mail: m.r.boyett@leeds.ac.uk

Adenosine exerts multiple receptor-mediated effects in the heart, including a negative chronotropic effect on the sinoatrial node. The aim of this study was to investigate the distribution of the equilibrative nucleoside transporter rENT1 in rat sinoatrial node and atrial muscle. Immunocytochemistry and/or immunoblotting revealed abundant expression of this protein in plasma membranes of sinoatrial node and in atrial and ventricular cells. Because rENT1-mediated transport is likely to regulate the local concentrations of adenosine in the sinoatrial node and other parts of the heart, it represents a potential pharmacological target that might be exploited to ameliorate ischemic damage during heart surgery. (J Histochem Cytochem 50:305–309, 2002)

Key Words: sinoatrial node, adenosine, rENT1, nucleoside, transport


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