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Journal of Histochemistry and Cytochemistry, Vol. 50, 455-462, April 2002, Copyright © 2002, The Histochemical Society, Inc.

ARTICLE

p73 Is Expressed in Human Thymic Epithelial Cells

Shingo Ichimiyaa, Takashi Kojimaa, Hiroyuki Momotaa, Nobuhiko Kondoa, Toshinori Ozakib, Akira Nakagawarab, María Luisa Toribioc, Masakatsu Imamuraa, and Noriyuki Satoa
a Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
b Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan
c Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain

Correspondence to: Noriyuki Sato, Dept. of Pathology, Sapporo Medical U. School of Medicine, South-1,West-17, Chuo-ku, Sapporo 060-8556, Japan. E-mail: nsatou@sapmed.ac.jp

The thymus is a heterogeneous immune organ in which immature T-cells develop and eventually specialize to make certain immune responses of their own. Among various types of stromal cells in the thymus, thymic epithelial cells (TECs) have a crucially important function for presenting self-antigens and secreting cytokines to thymocytes for their maturation into T-cells. In this study we show that the p73 gene, a homologue of the tumor suppressor gene p53, was expressed in the nucleus of the human TEC in vivo and in TEC lines in vitro. Because p73 has the capacity to be a transactivator like p53, it may contribute to T-cell development in the context of TEC biology as regulated in the cell cycle and apoptosis. (J Histochem Cytochem 50:455–462, 2002)

Key Words: p73, p53, human thymic epithelial cells


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