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Journal of Histochemistry and Cytochemistry, Vol. 50, 503-518, April 2002, Copyright © 2002, The Histochemical Society, Inc.

ARTICLE

Early Intracellular Events During Internalization of Listeria monocytogenes by J774 Cells

Paul Webstera
a House Ear Institute, Los Angeles, California

Correspondence to: Paul Webster, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057. E-mail: pwebster@hei.org

The gram-positive bacillus Listeria monocytogenes gains entry into host cells through a phagosome membrane that forms around entering bacteria. During the early stages of internalization the invading bacteria appear to modify the protein composition of the forming phagosome membrane in J774 cells. MHC class II molecules on the cell surface and exposed surface molecules available for biotinylation are excluded from the bacteria–host cell membrane interface and from the forming phagosome. This exclusion of MHC class II molecules from the early phagosome may partially help to explain previous reports suggesting that L. monocytogenes is able to interfere with antigen presentation. Inside the host cell, MHC class II molecules are delivered to the phagosome membrane. This is followed by delivery of LAMP 1, a marker of late endocytic compartments, and fusion with low-pH compartments. The bacteria then escape into the cell cytoplasm, possibly assisted by rapid delivery of this low-pH environment. (J Histochem Cytochem 50:503–517, 2002)

Key Words: electron microscopy, phagocytosis, macrophages, MHC class II, immunocytochemistry, lysosomes


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