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Journal of Histochemistry and Cytochemistry, Vol. 51, 513-522, April 2003, Copyright © 2003, The Histochemical Society, Inc.

ARTICLE

Expression of the LIM Proteins Paxillin and Hic-5 in Human Tissues

Tsutomu Yuminamochia, Yutaka Yatomib, Makoto Osadaa, Tsukasa Ohmorib, Yoshio Ishiia, Kumiko Nakazawaa, Shigemi Hosogayaa, and Yukio Ozakib
a Department of Clinical Laboratory, Yamanashi Medical University, Japan
b Department of Laboratory Medicine, Yamanashi Medical University, Japan

Correspondence to: Yutaka Yatomi, Dept. of Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi 409-3898, Japan. E-mail: yatomiy@res.yamanashi-med.ac.jp

The LIM domain is a protein–protein interaction motif critically involved in a variety of fundamental biological processes, including cytoskeletal organization, cell lineage specification, and organ development. In this study we examined the expression of the LIM proteins paxillin and Hic-5 in adult human tissues by immunohistochemistry and immunoblotting. Paxillin expression was widespread and observed both in non-muscle and muscle tissues. Of the latter, paxillin was mainly expressed in multinuclear striated muscle. In contrast, Hic-5 showed restricted expression and was expressed in muscle tissues, mainly in mononuclear smooth muscle. Taken together with previous findings, it appears likely that the counterbalance between paxillin and Hic-5 may be deeply involved in muscle differentiation. (J Histochem Cytochem 51:513–521, 2003)

Key Words: paxillin, Hic-5, LIM protein, focal adhesion, cytoskeletal reorganization, striated muscle, smooth muscle, human


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