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Journal of Histochemistry and Cytochemistry, Vol. 51, 1097-1099, August 2003, Copyright © 2003, The Histochemical Society, Inc.

BRIEF REPORT

P63 Immunoreactivity Distinguishes Upper Urinary Tract Transitional-cell Carcinoma and Renal-cell Carcinoma Even in Poorly Differentiated Tumors

Cord Langnera, Manfred Ratscheka, Oleksiy Tsybrovskyya, Luigi Schipsb, and Richard Zigeunerb
a Institute of Pathology, Karl Franzens University Graz, Graz, Austria
b Department of Urology, Karl Franzens University Graz, Graz, Austria

Correspondence to: Cord Langner, Dept. of Pathology, Karl Franzens University Graz, Auenbruggerplatz 25, A–8036 Graz, Austria. E-mail: cord.langner@uni-graz.at

P63 is essential for the differentiation of normal urothelium and is also expressed in transitional cell carcinoma (TCC) of the bladder. We investigated p63 immunoreactivity in upper urinary tract TCC (n=53) and in renal-cell carcinoma (RCC; n=188) using a tissue microarray technique. P63 expression was detected in 51/53 (96.2%) TCCs, showing decreased expression in high-stage (pT1 and pT2 100%; pT3 90.9%) and poorly differentiated (G1 and G2 100%; G3 92%) tumors. All RCCs were negative for p63. P63 proved to be a helpful tool, even in poorly differentiated and undifferentiated renal malignancies, to distinguish TCC from RCC. (J Histochem Cytochem 51:1097–1099, 2003)

Key Words: upper urinary tract, transitional-cell carcinoma, renal-cell carcinoma, immunohistochemistry, differential diagnosis


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