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Journal of Histochemistry and Cytochemistry, Vol. 51, 1109-1112, August 2003, Copyright © 2003, The Histochemical Society, Inc.

BRIEF REPORT

Distribution and Cellular Localization of Caldendrin Immunoreactivity in Adult Human Forebrain

Hans-Gert Bernsteina, Constanze I. Seidenbecherb, Karl-Heinz Smallaa, Eckart D. Gundelfingerb, Bernhard Bogertsa, and Michael R. Kreutzb
a Department of Psychiatry, Otto-von-Guericke-University, Magdeburg, Germany
b AG Molecular Mechanisms of Plasticity, Department of Neurochemistry/Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany

Correspondence to: Michael R. Kreutz, AG Molecular Mechanisms of Plasticity, Dept. of Neurochemistry/Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118 Magdeburg, Germany. E-mail: Kreutz@ifn-magdeburg.de

We investigated by immunohistochemistry (IHC) the distribution of caldendrin, the founding member of a novel family of neuronal calcium-binding proteins closely related to calmodulin, in human forebrain. Caldendrin immunoreactivity was unevenly distributed, with prominent staining in the paleo- and neocortex, hippocampus, and hypothalamus. With the exception of the hypothalamus, labeling was restricted to the somato–dendritic compartment of neurons. This distribution completely matches that reported in rat, indicating that the cellular function is most likely conserved among species. Therefore, one prerequisite for functional studies in rodent models aimed at elucidation of mechanisms with relevance for humans can be based on the present findings.

(J Histochem Cytochem 51:1109–1112, 2003)

Key Words: EF-hand proteins, dendrites, axons, pyramidal cells, interneuron, calcium-binding protein, calmodulin


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A. L. Tippens and A. Lee
Caldendrin, a Neuron-specific Modulator of Cav/1.2 (L-type) Ca2+ Channels
J. Biol. Chem., March 16, 2007; 282(11): 8464 - 8473.
[Abstract] [Full Text] [PDF]



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