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Journal of Histochemistry and Cytochemistry, Vol. 51, 1113-1118, September 2003, Copyright © 2003, The Histochemical Society, Inc.

RAPID COMMUNICATION

Concentration of Caveolin-3 at the Neuromuscular Junction in Young and Old Rat Skeletal Muscle Fibers

Bruce M. Carlsona,b,c, Jean A. Carlsona,c, Eduard I. Dedkova, and Ian S. McLennanc
a Department of Cell and Developmental Biology, University of Otago, Dunedin, New Zealand
b Institute of Gerontology, University of Otago, Dunedin, New Zealand
c University of Michigan, Ann Arbor, Michigan, and Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand

Correspondence to: Bruce M. Carlson, Inst. of Gerontology, University of Michigan, 300 North Ingalls Bldg., Room 913, Ann Arbor, MI 48109. E-mail: brcarl@umich.edu

Caveolin-3, a muscle-specific member of the caveolin family, is strongly localized to the neuromuscular junction (NMJ) in adult rat muscle fibers, where it co-localizes with {alpha}-bungarotoxin staining. In 24-month-old rats, less distinct staining corresponds with the normal aging changes in the NMJ. After denervation, the pattern and intensity of staining begin to break up as early as 3 days, and by 10 days little staining remains. The functional implications of this concentration of caveolin-3 at the NMJ remain obscure, but it is possible that its absence could account for some of the phenotypic characteristics of individuals with caveolin-3 mutations. (J Histochem Cytochem 51:1113–1118, 2003)

Key Words: caveolin-3, neuromuscular junction, rats, aging, denervation, immunohistochemistry, muscle fiber isolation


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