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Journal of Histochemistry and Cytochemistry, Vol. 51, 1245-1248, September 2003, Copyright © 2003, The Histochemical Society, Inc.

BRIEF REPORT

Immunolocalization of Sperm Protein 17 in Human Testis and Ejaculated Spermatozoa

Fabio Grizzia,b, Maurizio Chiriva–Internatic, Barbara Franceschinia,b, Paul L. Hermonatd, Giuseppe Sodae, Seah H. Limc, and Nicola Dioguardia,b
a Scientific Direction, Istituto Clinico Humanitas, Rozzano, Milan, Italy
b Fondazione "Michele Rodriguez," Istituto Scientifico per le Misure Quantitative in Medicina, Milan, Italy
c Texas Tech University Health Science Center, and Don and Sybil Harrington Cancer Center, Amarillo, Texas
d Division of Obstetrics and Gynecology, University of Arkansas Medical Sciences, Little Rock, Arkansas
e Department of Experimental Medicine and Pathology, University of Rome "La Sapienza," Rome, Italy

Correspondence to: Fabio Grizzi, Istituto Clinico Humanitas, Scientific Direction, Via Manzoni 56, 20089 Rozzano MI, Italy. E-mail: fabio.grizzi@humanitas.it

Sperm protein 17 (Sp17) is a highly conserved mammalian protein whose primary function is still poorly understood. Immunohistochemistry (IHC) in the human testis reveals the presence of Sp17 in some spermatocytes and abundantly in spermatids. All spermatogonia, Sertoli cells, and Leydig cells appear to be immunonegative for Sp17, whereas some interstitial cells are immunopositive. IHC recognized two distinct populations (immunopositive or not for Sp17) in the ejaculated spermatozoa. Although it will be necessary to clarify why some ejaculated spermatozoa do not contain Sp17, its distribution suggests that this protein may be associated with some phases of germinal cell differentiation.

(J Histochem Cytochem 51:1245–1248, 2003)

Key Words: sperm protein 17, testis, spermatogenesis, immunohistochemistry


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