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Sperm Protein 17 Is Expressed in Human Somatic Ciliated Epithelia

Fabio Grizzi¹, Maurizio Chiriva–Internati¹, Barbara Franceschini, Klaus Bumm, Piergiuseppe Colombo, Michele Ciccarelli, Elena Donetti, Nicoletta Gagliano, Paul L. Hermonat, Robert K. Bright, Magda Gioia, Nicola Dioguardi and W. Martin Kast

Scientific Direction (FG,BF,ND), Pathology Department (PC) and Internal Medicine Unit (MC), Istituto Clinico Humanitas, Rozzano, Milan, Italy; Michele Rodriguez Foundation, Institute for Quantitative Measures in Medicine (FG,BF,ND), Milan, Italy; Department of Microbiology and Immunology, Texas Tech University Health Science Center (MC–I,KB,RB), Lubbock, Texas; Department of Human Anatomy, University of Milan (ED,NG,MG), Milan, Italy; Division of Obstetrics and Gynecology, University of Arkansas Medical Sciences (PLH), Little Rock, Arkansas; and Norris Comprehensive Cancer Center, University of Southern California (WMK), Los Angeles, California

Correspondence to: Maurizio Chiriva–Internati, Dept. of Microbiology and Immunology, Southwest Cancer Center, Texas Tech University Health Sciences Center, 3601 4th St., 5B191, Lubbock, TX 79430. E-mail: Maurizio.ChirivaInternati{at}ttuhsc.edu

It was once believed that sperm protein 17 (Sp17) was expressed exclusively in the testis and that its sole function was to bind to the oocyte during fertilization. However, immunohistochemistry of the human respiratory airways and reproductive systems show that it is abundant in ciliated cells but not in human cells with stereocilia and microvilli. The high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP)-binding motif within this region, suggest that Sp17 plays a regulatory role in a PKA-independent AKAP complex in both male germinal and ciliated somatic cells. (J Histochem Cytochem 52:549–554, 2004)

Key Words: sperm protein 17 • respiratory system • reproductive system • cilia • microvilli • immunohistochemistry

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