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Journal of Histochemistry and Cytochemistry
Volume 52 (5): 591-602, 2004
Copyright ©The Histochemical Society, Inc.

An Immunohistochemical Study of the Expression of Adhesion Molecules in Gallbladder Lesions

Yoon-La Choi, Yan Hua Xuan, Young Kee Shin, Seoung Wan Chae, Myeong Cherl Kook, Ro Hyun Sung, Sei Jin Youn, Jae Woon Choi and Seok Hyung Kim

Department of Pathology (YHX,RHS,SHK), Chungbuk National University, College of Medicine, Chungbuk, Korea; Department of Pathology (Y-LC), Samsung Medical Center, Sungkyunkwan University, College of Medicine, Sungkyunkwan, Korea; Department of Pharmacy (YKS), Seoul National University, College of Pharmacy, Seoul, Korea; Department of Pathology (SWC), Sungkyunkwan University, College of Medicine, Sungkyunkwan, Korea; DiNonA, Inc. (YKS), Seoul, Korea; Department of Pathology (MCK), Seoul National University, College of Medicine, Seoul, Korea; Departments of Internal Medicine (SJY) and Surgery (JWC), Chungbuk National University, College of Medicine, and Chungbuk National University, Medical Research Institute (SHK), Chungbuk, Korea; and Department of Pathology (YHX), YanBian University, College of Medicine, YanBian, China

Correspondence to: Seok Hyung Kim, Dept. of Pathology, Chungbuk National University Hospital, 62 Kaesin-dong, Cheongju, Chungbuk, South Korea 361-763. E-mail: platoshkim{at}freechal.com

We investigated the expression of 10 adhesion molecules ({alpha}-catenin, ß-catenin, {gamma}-catenin, CD44, CD44v6, ICAM-1, CD56, CEA, E-cadherin, and CD99) in 46 gallbladder carcinomas, 14 adenomas, 15 low-grade dysplasias, nine intestinal metaplasias, and 20 samples of normal gallbladder epithelium by immunohistochemistry. The expression of adhesion molecules was altered in gallbladder carcinomas and adenomas. In gallbladder carcinomas, increased expression of ICAM-1, CEA, and CD44v6 was observed, together with decreased expression of {alpha}/ß/{gamma}-catenin and CD99. In adenomas, aberrant expression of CD44v6 and CD56, as well as reduced expression of {alpha}/ß/{gamma}- and E-cadherins, was noted. Expression of {alpha}/ß/{gamma}-catenin was reduced in low-grade dysplasia, whereas there was no change in the expression of these adhesion molecules in metaplasia. Expression of ICAM-1, CD99, E-cadherin, and CD56 was correlated with clinical stage. In addition a correlation was noted between expression of ICAM-1 and E-cadherin and lymph node metastasis (p<0.05). These results suggest that altered expression of these adhesion molecules is involved in the progression and metastasis of gallbladder carcinomas.

(J Histochem Cytochem 52:591–601, 2004)

Key Words: gallbladder • catenin • CD44 • CD44v6 • ICAM-1 • CD56 • CEA • E-cadherin • CD99 • immunohistochemistry


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