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Journal of Histochemistry and Cytochemistry
Volume 52 (5): 705-708, 2004
Copyright ©The Histochemical Society, Inc.

BRIEF REPORT

C-kit Gene Product (CD117) Immunoreactivity in Canine and Feline Paraffin Sections

Maria Morini, Giuliano Bettini, Rosario Preziosi and Luciana Mandrioli

Department of Veterinary Public Health and Animal Pathology, Alma Mater Studiorum, University of Bologna, Bologna, Italy

Correspondence to: Dott.ssa Maria Morini, Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Servizio di Anatomia Patologica, Facoltà di Medicina Veterinaria, Via Tolara di Sopra, 50 40064 Ozzano Emilia (Bologna), Italy. E-mail: bettini{at}vet.unibo.it

CD117 is a transmembrane tyrosine kinase growth factor receptor expressed by a variety of normal human cell types, including germ cells, immature myeloid cells, and mast cells. To evaluate the pattern of CD117 expression in dogs and cats, we applied a polyclonal antibody on paraffin sections from 44 samples of normal tissues and 104 tumors. In both species, strong immunoreactivity was observed in mast cells, interstitial cells of Cajal, and in mast cell tumors. Among gastrointestinal mesenchymal neoplasms, tissues from five dogs and one cat revealed strong CD117 expression, enabling us to identify them as gastrointestinal stromal tumors (GISTs). (J Histochem Cytochem 52:705–708, 2004)

Key Words: CD117 • c-kit • dog • cat • immunohistochemistry • mast cell tumors • GIST


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