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Originally published as JHC exPRESS on December 12, 2005.
doi:10.1369/jhc.5A6755.2005
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Journal of Histochemistry and Cytochemistry
Volume 54 (4): 467-472, 2006
Copyright ©The Histochemical Society, Inc.

Expression of Tandem P Domain K+ Channel, TREK-1, in the Rat Carotid Body

Y. Yamamoto and K. Taniguchi

Laboratory of Veterinary Anatomy, Faculty of Agriculture, Iwate University, Morioka, Japan

Correspondence to: Y. Yamamoto, Laboratory of Veterinary Anatomy, Department of Veterinary Sciences, Faculty of Agriculture, Iwate University, Ueda 3-19-8, Morioka, Iwate 080-8550, Japan. E-mail: yyoshio{at}iwate-u.ac.jp

TREK-1 is one of the important potassium channels for regulating membrane excitability. To examine the distribution of TREK-1 in the rat carotid body, we performed RT-PCR for mRNA expression and in situ hybridization and immunohistochemistry for tissue distribution of TREK-1. RT-PCR detected mRNA expression of TREK-1 in the carotid body. Furthermore, in situ hybridization revealed the localization of TREK-1 mRNA in the glomus cells. TREK-1 immunoreactivity was mainly distributed in the glomus cells and nerve fibers in the carotid body. TREK-1 may modulate potassium current of glomus cells and/or afferent nerve endings in the rat carotid body. (J Histochem Cytochem 54:467–472, 2006)

Key Words: 2P-domain potassium channel • carotid body • membrane potential • immunocytochemistry • rat


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