Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
Originally published as JHC exPRESS on July 11, 2007.
doi:10.1369/jhc.7A7188.2007
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jhc.7A7188.2007v1
55/11/1089    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xin, X.
Right arrow Articles by Meyer, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xin, X.
Right arrow Articles by Meyer, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry
Volume 55 (11): 1089-1094, 2007
Copyright ©The Histochemical Society, Inc.

Septin Expression in Proliferative Retinal Membranes

Xiaorong Xin, Mona Pache, Barbara Zieger, Ingrid Bartsch, Christian Prünte, Josef Flammer and Peter Meyer

Department of Ophthalmic Pathology (XX,PM), University Eye Clinic (CP,JF), University of Basel, Basel, Switzerland; Department of Ophthalmology, Qinghai Provincial People's Hospital, Xining, Qinghai, China (XX); and University Eye Hospital (MP), Department of Pediatrics and Adolescent Medicine (BZ,IB), University of Freiburg, Freiburg, Germany

Correspondence to: Peter Meyer, MD, Department of Ophthalmic Pathology, University of Basel, PO Box CH-4012, Basel, Switzerland. E-mail: peter.meyer{at}unibas.ch

We undertook this study to evaluate the expression of septin family members SEPT5, SEPT8, and SEPT11 in proliferative retinal membranes. Epiretinal membranes (ERM) were obtained from seven patients with proliferative vitreoretinopathy (PVR) and from four patients and four postmortem eyes with proliferative diabetic retinopathy (PDR). Subretinal membranes (SRM) were obtained from one patient and six postmortem eyes. Membranes were examined by immunohistochemical staining of paraffin sections using polyclonal antibodies against SEPT5, SEPT8, and SEPT11 and an ABC detection system. SEPT8 expression was detected in all ERM and SRM, with an exceptionally strong expression of 100% for ERM of PVR, 63% for PDR membranes, and 57% for SRM. SEPT11 was identified in 91% of all cases, with strong expression of 14%, 25%, and 14% in ERM of PVR, PDR, and SRM, respectively. SEPT5 was seen in 54% of all cases; strong immunostaining was found in only one case of PVR membranes. Our finding suggests a role for members of the septin family in the development of proliferative retinal membranes. (J Histochem Cytochem 55:1089–1094, 2007)

Key Words: SEPT5 • SEPT8 • SEPT11 • proliferative vitreoretinopathy • proliferative diabetic retinopathy • epiretinal membrane • subretinal membrane


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?





Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2007