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Originally published as JHC exPRESS on November 13, 2006.
doi:10.1369/jhc.6A7032.2006
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Journal of Histochemistry and Cytochemistry
Volume 55 (3): 223-234, 2007
Copyright ©The Histochemical Society, Inc.

Immunohistochemical Analysis of ZnT1, 4, 5, 6, and 7 in the Mouse Gastrointestinal Tract

Yan Yiu Yu, Catherine P. Kirschke and Liping Huang

United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center (CPK,LH), Department of Nutrition (YYY,LH), and Rowe Program in Genetics (LH), University of California at Davis, Davis, California

Correspondence to: Dr. Liping Huang, 430 West Health Sciences Drive, WHNRC, UC Davis, Davis, CA 95616. E-mail: lhuang{at}whnrc.usda.gov

Expression of five zinc transporters (ZnT1, 4, 5, 6, and 7) of the Slc30 family in the mouse gastrointestinal tract was studied by immunohistochemical analysis. Results demonstrated unique expression patterns, levels, and cellular localization among ZnT proteins in the mouse gastrointestinal tract with some overlapping. ZnT1 was abundantly expressed in the epithelium of the esophagus, duodenum of the small intestine, and cecum of the large intestine. ZnT4 was predominantly detected in the large intestine. ZnT5 was mainly expressed in the parietal cell of the stomach and in the absorptive epithelium of the duodenum and jejunum. ZnT6 was predominantly detected in the chief cell of the stomach, columnar epithelial cells of the jejunum, cecum, colon, and rectum. Lastly, ZnT7 was observed in all epithelia of the mouse gastrointestinal tract with the highest expression in the small intestine. Expression of ZnT proteins in the absorptive epithelial cell of the gastrointestinal tract suggests that ZnT proteins may play important roles in zinc absorption and endogenous zinc secretion. (J Histochem Cytochem 55:223–234, 2007)

Key Words: zinc transporters • Slc30 family • ZnT • dietary zinc absorption • gastrointestinal tract


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[Abstract] [Full Text] [PDF]



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