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THE HISTOCHEMISTRY OF SIALIC ACID CONTAINING MUCOPROTEINS

S. S. SPICER 1 and L. WARREN 1

1 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda 14, Maryland

Sialidase digestion of histological sections releases sialic acid from some sialic acid rich nonsulfated mucins. Such treatment eliminates the metachromatic staining and alcian blue affinity of these mucopolysaccharides. The procedure furnishes a method for histochemical localization of certain sialomucins.

Submitted on July 17, 1959


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