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JHC exPRESS: First Published November 12, 2007. doi:10.1369/jhc.7A7290.2007
Copyright © Histochemical Society, Inc.

A more recent version of this article appeared on March 1, 2008.
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Articles

Aberrant Expression of Histo-blood Group A Type 3 Antigens in Vascular Endothelial Cells in Inflammatory Sites

Mizuho Nosaka 1, Yuko Ishida 1, Aki Tanaka 1, Takahito Hayashi 1, Tomoko Miyashita 1, Chikako Kaminaka 1, Wolfgang Eisenmenger 1, Fukumi Furukawa 1 and Akihiko Kimura 1*

1 Department of Forensic Medicine (MN,YI,TH,TM,AK) and Department of Dermatology (AT,CK,FF), Wakayama Medical University, Wakayama, Japan, and Institute of Legal Medicine, University of Munich, Munich, Germany (WE)

* To whom correspondence should be addressed. E-mail: legkim{at}wakayama-med.ac.jp.

Submitted on July 9, 2007
Accepted on 31 October 2007


  Abstract
Histo-blood group ABH antigens are widely distributed in human tissues. The epitopes of ABH antigens are carried by at least four different peripheral core isotypes of internal carbohydrate backbones (type 1-4). Each type of ABH antigen is expressed tissue-specifically, and aberrant expression of ABH antigens is often observed during oncogenesis. We immunohistochemically examined the expression of A type 3 antigens in wounded and diseased skin tissues (A and AB blood groups). In uninjured skin, the expression of A type 3 antigens was restricted to the eccrine sweat gland. In addition to the sweat glands, A type 3 antigens were found in vascular endothelial cells of the wound sites. The extent of A type 3 antigens expression related to post infliction intervals. A significantly higher expression rate of A type 3 antigens in endothelial cells was also observed in diseased skin, suggesting that inflammatory might induce A type 3 antigen expression in endothelial cells. Double-color immunofluorescence staining of the specimens demonstrated that von Willebrand factor (vWF) was a core-protein of A type 3 determinants aberrantly expressed in endothelial cells in inflamed tissues, suggesting that aberrant expression of A type 3 antigens is involved in stabilization of vWF in inflammation.

Key Words: histo-blood group A type 3 antigen, vascular endothelial cell, wound healing, inflammation, von Willebrand factor


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